Our goal is to revolutionise the management of patients with liver disease.
We are developing treatments that target the disruption to gut bacteria (gut dysbiosis) in patients with liver disease. These bacteria naturally produce breakdown products (endotoxins or lipopolysaccharides) that cause serious problems if they cross the intestinal wall. Our technologies remove these breakdown products from the intestine and from the blood with the goal of prolonging patients survival and improving quality of life. The breakthroughs made by University College London doctors and scientists, led by Professor Rajiv Jalan, in the understanding of liver disease are being tested by Yaqrit in human clinical trials starting in 2017. Results will begin to be available from 2018, and will be reported on this website.
Glossary of Liver Disease Terms
Cirrhosis - the primary liver disease where the liver does not function properly due to long term damage, which is most often caused by factors including alcohol, obesity, hepatitis and drug use, but also caused by clinical issues such as autoimmune diseases, medication side effects and cancer.
ACLF - Acute-on-Chronic Liver Failure - The rapid development of liver failure in a patient with long-term liver damage which was caused by cirrhosis - there are more than 200,000 cases per year in the US and Europe.
NASH - Non-Alcoholic Steato-Hepatitis - a fatty deposit liver disease due to causes other than alcohol, eg obesity, diabetes or non-alcohol related cirrhosis.
HE - Hepatic encephalopathy (HE) - a debilitating brain disease which is a result of cirrhosis or liver failure.
NAFLD - Non-Alcoholic Fatty Liver Disease - a common disorder where there is accumulation of excess fat in the liver of people who drink little or no alcohol. The most common form of NAFLD is a non-serious condition called fatty liver - more than 10% of the population suffers from NAFLD.
AH - Alcoholic Hepatitis - inflammation of the liver, usually due to excessive alcohol consumption, usually associated with fatty liver and a stage of ALD below.
ALD - Alcoholic Liver Disease - a term that encompasses all alcohol-related liver diseases. About 20% of people with some form of ALD go on to develop cirrhosis or hepatitis.
Patient related links
www.britishlivertrust.org.uk - The British Liver Trust
www.liverfoundation.org - The American Liver Foundation
www.aasld.org/ - American Association for the Study of Liver Diseases
www.easl.eu/ - European Association for the Study of the Liver
http://www.efclif.com/ - European Foundation for the Study of Chronic Liver Failure
https://clinicaltrials.gov/ - a registry and database of public and private clinical studies around the world